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Malvern Instruments acquires Viscotek Corporation
Thursday, January 17, 2008
Malvern, UK: Materials characterization company Malvern Instruments has acquired Viscotek Corporation, a leading provider of chromatography solutions for the characterization of natural and synthetic polymers and proteins.

Malvern Instruments is a world-class supplier of systems for the characterization of particulate materials, providing complete application solutions across a broad range of industries. The acquisition of Viscotek brings new and complementary technologies and expertise into the company, adding Gel Permeation Chromatography (GPC), Flow Injection Polymer Analysis (FIPA) and Dilute Solution Viscosity (DSV), and extending the range of characterization solutions offered.

Paul Walker, Managing Director of Malvern Instruments said: “Viscotek has a long-established reputation for innovation and quality, and there is a close and complementary fit between the Viscotek product range and Malvern’s, for both protein and polymer applications. This acquisition will increase the characterization capabilities of Malvern’s existing nanometrology product lines.”

Viscotek Corporation, headquartered in Houston, Texas, was founded in 1984 by Dr. Max Haney, inventor of the four-capillary differential viscometer detector. “Since its inception, Viscotek has pioneered innovative technologies and products for gel permeation chromatography of natural and synthetic polymers and proteins, and determination of dilute solution viscosities,” he said. “In recent years Viscotek has experienced exciting growth. The powerful alignment of Viscotek’s products with the Malvern range will provide even more opportunity to comprehensively meet a broad range of customer needs. I am delighted that the company has become part of Malvern Instruments, where I am confident of further development and a thriving and expanded business.”

Expanding on the complementary nature of the two companies’ product ranges, Paul Walker went on to say: “In the biomolecular arena the addition of Viscotek systems alongside our existing product range will further inform physical biochemists of the structure-function relationship of proteins, important in determining disease mechanisms for example. In the field of industrial and pharmaceutical polymers, Malvern will now be able to offer complete characterization solutions, essential in the development of new functional polymers that meet the demands of increasingly complex drug delivery systems and stringent environmental requirements.

“Through Malvern’s global sales organization, customers worldwide will have access to the full range of solutions, all backed by the company’s extensive technical and applications support network.”

Viscotek’s present management team will continue to lead the business, which will operate as Viscotek Corporation, a Malvern Company.

For further information about the Malvern and Viscotek ranges please visit www.malvern.com and www.viscotek.com

Malvern and Malvern Instruments are registered trademarks of Malvern Instruments Ltd. Viscotek is a registered trademark of Viscotek Corp.

Analysis of polymers only soluble at elevated temperatures
Wednesday, October 31, 2007
The Viscotek Model 350 High Temperature GPC (HT-GPC) System is a revolutionary advanced detector system specifically designed for the characterisation of polyolefins, and other synthetic polymers that are soluble only at elevated temperatures.

The Model 350 HT-GPC system provides absolute molecular weight without extrapolation or correction, molecular size (Rg and Rh to less than 1 nm), and intrinsic viscosity, as well as information on branching, structure and aggregation in a single GPC/SEC experiment. The system may also be configured with an Infrared (IR) Detector for short-chain branching analysis or a UV/VIS detector for copolymer compositional analysis.

Representing a breakthrough in high temperature technology, the new system includes a High Temperature Triple Detector Array (HT-TDA), an Automated sample preparation & delivery system, a pulseless isocratic Pump, Degasser and OmniSEC GPC software for complete system control, data acquisition and processing. Engineered in a modular format for flexibility and enhanced reliability, the Model 350 HT-GPC features a detector module (HT-TDA) that is easily removed from the high temperature environment for routine maintenance.

The Viscotek Model 350 HT-TDA combines low angle light scattering with viscometry and concentration for complete and comprehensive macromolecular characterisation. All detectors reside within a temperature-controlled oven compartment (30 -175 degrees C) which has space for four analytical GPC columns. The 350 HT-TDA also features an in-line, self-cleaning filter and can be configured with only an RI, an RI and viscometer, an RI and light scattering detector or as a full Triple Detector Array.

Founded in 1985, Viscotek GPC / SEC detectors, software and systems are in daily use in 1000's of leading research, quality control and process development laboratories worldwide. Viscotek's innovative products and technologies are backed throughout Europe, North America and Asia by superior technical service and analytical support.

For further information on the Model 350 HT-GPC please contact Viscotek on telephone +44-1344 467180 or email info@viscotek-europe.com

Triple Detection GPC - a powerful tool for characterising polysaccharides
Thursday, July 19, 2007
Viscotek has produced a series of new application notes demonstrating how precise and comprehensive characterisation of different polysaccharides can be achieved with its unique Triple Detection GPC system.

Chitosans are a focus of interest for various applications. They can be used in a range of medical applications as they are biocompatible, hypoallergenic, biodegradable and bioabsorbable. Triple Detection Application Note 7 examines how physical processing of chitosan samples can directly affect characteristic properties, such as molecular weight distribution, size and conformation. The application note demonstrates how by using the Triple Detector approach, changes in molecular structure and molecular chain length can be simultaneously and independently monitored.

Many hydrocolloids such as agar, pectin, gelatine and carrageenan find application as thickening, gelling and stabilising agents in products such as frozen desserts, chocolate milk, yoghurt and toothpaste. In the application note 'Structural Distribution of Carrageenan Samples' - a Viscotek Triple Detection GPC system and OmniSEC software is used to fully characterise three carrageenan samples at elevated temperature to ensure complete dissolution. Data is provided demonstrating how the tripe detection technique provides valuable information on chain conformation as well as the structural distribution of the Kappa, Iota and Lambda forms of this complex naturally occurring polymer in a single experiment.

Maltodextrins are produced from the degradation of starch, often by the use of enzymes. The products are widely used as ingredients in food and pharmaceutical products. Because maltodextrins are derived from starch they are a mixture of both linear and branched molecules. This can lead to large errors if they are characterised by conventional GPC. The application note 'Analysis of Maltodextrins' shows how the use of Triple Detection GPC can clearly measure the differences in both structure and molecular weight for 3 maltodextrins with similar bulk viscosities but very different end-use properties. Triple Detection sets the standard for GPC/SEC technology and is the preferred method for even complex polysaccharides. The Viscotek Triple Detector System (TDA™) employs a concentration detector, viscometer and Low Angle Light Scattering (LALS) detector acting in concert, with each detector providing complimentary but different information. Using LALS to measure molecular weights is extremely important when studying large biomolecules such as polysaccharides. Other extrapolation based light scattering techniques, such as those using multi angle detectors, cannot be used because the large molecule sizes result in large data fitting errors. By comparison the Viscotek LALS detector measures scattered light at 7 degrees, close enough to zero that the measurement is direct with no need to extrapolate or calculate to get accurate molecular weight and structure data.

The application notes demonstrate however that it is the combination of the three detectors acting in concert that allows the Viscotek TDA system to unlock molecular weight distribution, viscosity, molecular size, conformation and branching frequency data from the polysaccharide samples.

For copies of these application notes or further information on Triple Detection GPC please contact Viscotek.

Dual detector provides entry-level access to powerful Biomolecular characterisation
Thursday, June 21, 2007
The Model 270 Dual Detector from Viscotek (www.viscotek.com) has been designed to simply add to any existing GPC/SEC system equipped with a concentration detector, instantly converting it into a powerful triple detector system.

The Model 270 Dual Detector is the perfect entry-level system for laboratories looking to make detailed characterisation of biomolecules including polysaccharides, DNA, antibodies, proteins and protein conjugates.

The Model 270 Dual Detector features a proven four-capillary differential viscometer and revolutionary Low Angle Light Scattering (LALS) detector that operate at ambient temperature. The viscometer measures intrinsic viscosity and can be used to determine molecular size (Rh to less than 1nm) and density. The viscometer can also be used to provide additional valuable information on structure, conformation, aggregation and branching. Unlike multi-angle light scattering techniques that can only determine molecular weight by extrapolation, the Model 270 LALS detector measures molecular weight directly and thus is inherently more accurate.

Founded in 1985, Viscotek GPC / SEC detectors, software and systems are in daily use in 1000's of leading research, quality control and process development laboratories worldwide. Viscotek's innovative products and technologies are backed throughout Europe, North America and Asia by superior technical service and analytical support.

For further information on the Model 270 Dual Detector please contact Viscotek.

GPC/SEC characterisation of copolymers and conjugated proteins
Tuesday, April 24, 2007
The Tetra Detector System from Viscotek (www.viscotek.com) provides a unique tool for characterising complex molecules including copolymers and conjugated proteins.

Combining the power of RI, UV, Viscometry and Low Angle Light Scattering (LALS) detectors acting together, with each detector providing complimentary but different information, the Tetra Detector is the most powerful GPC/SEC system available today. When integrated with the GPCmax (pump, autosampler, degasser) and OmniSEC software the Tetra Detector system is able to cope with even the most demanding analyses.

By ratioing the response from the two concentration detectors the system corrects the limitations of using a single detector by delivering rapid determination of a true copolymer or conjugated protein concentration profile. Using the viscometry and LALS detectors the Tetra Detector system enables users to obtain absolute molecular weight, molecular size (to less than 1 nm) and intrinsic viscosity as well as information on branching, conformation, aggregation and composition from their sample. Maintained in a thermostatically controlled environment the TDA has the sensitivity and stability to repeatably characterise copolymers and conjugated proteins even at low concentrations.

Founded in 1985, Viscotek GPC / SEC detectors, software and systems are in daily use in 1000's of leading research, quality control and process development laboratories worldwide. Over the years Viscotek has built an online reference list of several hundred customer technical articles covering applications of GPC/SEC technology, peptide and protein analysis, flow injection polymer analysis and dilute solution viscometry.

A pdf brochure describing the Tetra Detector system in more detail can be downloaded from http://www.viscotek.com/triple_detector_array_with_LALS_and_UV.php4 For further information please contact Viscotek on telephone +44-1344 467180 or email info@viscotek-europe.com

Informative text on Dynamic Light Scattering instrumentation
Tuesday, March 27, 2007
A new 8-page technical brochure is available from Viscotek - that describes its recently launched second generation Model 802 Dynamic Light Scattering (DLS) instrument.

For those new to DLS the new brochure provides background to the technique and applications of dynamic light scattering. Further well illustrated text provides an in-depth review of the performance advantages born out of Viscotek's exclusive single mode fibre technology as well as introducing a range of exciting new technical innovations pioneered in the new generation Model 802 DLS.

Designed for laboratories that need a complete understanding of how their protein, biopolymer or nanoparticulate material behaves in solution the new ergonomically designed Model 802 DLS sets a new standard for superior sensitivity, resolution, accuracy and sampling versatility compared to any other light scattering instrument currently available.

Traditionally laboratories faced with analysing higher concentration samples, such as emulsion or nanoparticles, have found traditional light scattering instruments limited both in terms of sensitivity and resolution. To address these deficiencies Viscotek developed as an option for its new generation system - Dual Attenuation Technology. Dual Attenuation Technology (DAT) is a unique technique that controls the level of light entering the sample as well as controlling scattered light going to the detector. In this way, for the first time, researchers are able to work at the optimum conditions for the laser and detector irrespective of sample type. In combination with OmniSIZE 3.0 software the new generation Model 802 DLS with DAT is able to automatically adjust the instrument to its optimum setting sample by sample. From 100% transmission for the maximum sensitivity right down to 0.0001% transmission for concentrated samples - a dynamic range of 106. Further innovations introduced on the new Model 802 DLS include a 544-channel correlator that provides, as standard, industry leading resolution and distribution accuracy. In addition to operating up to 90°C the new instrument now incorporates digital sensors that provide automatic environmental control as well as real-time humidity and dew point information.

Founded in 1985, Viscotek is the global leader in Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) detectors, software and systems for the characterisation of natural and synthetic polymers, copolymers, proteins, protein conjugates and nanoparticulate materials. Viscotek's innovative products and technologies are backed in Europe, North America and Asia by superior technical service and analytical support.

For a copy of the new generation Model 802 DLS instrument brochure please contact Viscotek on telephone +44-1344-467180 or email info@viscotek-europe.com

State-of-the-art DLS microplate instrument
Monday, February 26, 2007
Viscotek, market leader in multi-detector characterisation of polymers, proteins and nanoparticulate materials, has announced the launch at Pittcon 2007 this week of a new state-of-the-art DLS microplate instrument - the HorizonDLS ™.

Incorporating Viscotek's patented Single Mode Fibre (SMF) optical detection, unique Dual Attention Technology (DAT) and independent temperature control of microplate and sample the new HorizonDLS™ sets a new benchmark for automated biomolecular characterisation.

The HorizonDLS™ delivers the same unmatched sensitivity on ultra low sample volumes as the acclaimed Model 802 DLS, but automatically, from the entire plate or selected wells, with no user interaction required. After manual or robotic placement of a prepared microplate into the temperature controlled instrument - intuitive OmniSIZE™ software then automatically makes the measurements according to the user programmed acquisition sequence and the results are displayed in seconds. A complete size distribution of an entire microplate can be automatically accomplished in just minutes

The HorizonDLS™ uniquely delivers both productivity and performance to a broad range of applications including screening of aggregates prior to protein crystallisation, monitoring size and aggregation as a function of varying solution conditions, buffer optimisation and characterisation and screening biotherapeutics for self-association. All laboratories involved in biomolecular characterisation require a complete understanding of how their proteins and other biomolecules function in solution. Stability, conformation, aggregation and complex formation are all important issues facing a wide variety of research and development laboratories. The Viscotek HorizonDLS™ is an essential tool that can provide this information in a fast, accurate and user-friendly manner.

Founded in 1985, Viscotek is the global leader in GPC / SEC detectors, software and systems for the characterisation of polymers, proteins and nanoparticles. Launched in 2005 Viscotek's innovative Model 802 DLS instrument has been widely acclaimed by laboratories around the world particularly those specialising in biomolecular discovery, development and delivery, protein-protein interactions, protein conformation analysis and measurement of the stability and size of lipids and conjugates.

For more information on the HorizonDLS™, please visit booth 3838 at Pittcon 2007 or alternatively contact Viscotek by email on info@viscotek-europe.com (Europe) or info@viscotek.com (North America / ROW).

New product bonanza for polymer & protein scientists
Wednesday, January 31, 2007
New product bonanza for polymer & protein scientists ..

Viscotek, leaders in multi-detector characterisation of proteins, polymers and nanoparticulate materials, has announced a series of new product introductions will be made at Pittcon 2007 in Chicago, IL (USA).

At this important meeting - Viscotek will launch its new High Throughput Dynamic Light Scattering (HTDLS) instrument. Combining the proven benefits of Viscotek's patented single mode fibre (SMF) technology and an entirely new 3-axis, automated platform - the HTDLS is a truly high throughput, dynamic light scattering system unhindered by compromise. The HTDLS delivers the highest sensitivity, wide range temperature control and low sample volume allowing you to make the most of your assays, whatever plate types you choose to use. Achieving market-leading performance, the HTDLS cuts down measurement times to c. 1 minute per sample well.

Traditionally laboratories faced with analysing higher concentration samples, such as emulsion or nanoparticles, have found traditional light scattering instruments limited both in terms of sensitivity and resolution. To address these deficiencies Viscotek has launched the Model 802- DAT. Dual Attenuation Technology (DAT) is a unique technique that controls the level of light entering the sample as well as controlling scattered light going to the detector. In this way, for the first time, researchers are able to work at the optimum conditions for the laser and detector irrespective of sample type. In combination with OmniSIZE 3.0 software the new generation Model 802 DLS with DAT is able to automatically adjust the instrument to its optimum setting sample by sample. From 100% transmission for the maximum sensitivity right down to 0.0001% transmission for concentrated samples - a dynamic range of 10 6.

Visitors to Booth 3838 will also have the chance see and discuss the latest versions of the company's market leading multi-detector GPC/SEC systems - the Triple Detector Array (TDA) and the GPCmax. Viscotek triple detection systems, which employ a concentration detector, viscometer and light scattering detector operating in concert, are today the defacto standard for the characterisation of natural and synthetic polymers and proteins in the petrochemical, specialty chemical, elastomers, adhesives, coatings, food, agricultural, academic, pharmaceutical and biotechnology markets.

For scientists looking to characterise and quantitate polymers in the production environment Viscotek will be showing its popular FIPA system and the latest version of its Model 501 Dilute Solution Viscometer (DSV). To automate acquisition and processing of data Viscotek has consulted with industry users to produce new Automated Relative Viscometry software. Based upon Viscotek's patented Y501 viscometer design the Y501 ARV system measures solvent and sample viscosity simultaneously, avoiding errors due to temperature fluctuations and solvent variations. The system provides faster analysis, greater precision and less solvent exposure when compared to the traditional Ubbelohde or Cannon-Fenske glass tube viscometers that it replaces.

Founded in 1985, Viscotek's innovative products and technologies are backed in Europe, North America and Asia by superior technical service and analytical support.

For more information on Viscotek's product innovations and services, please visit booth 2138 at Pittcon 2007 or alternatively, please visit www.viscotek.com or e-mail info@viscotek-europe.com (Europe) / info@viscotek.com (North America).

Complete Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) systems for the characterization of natural and synthetic polymers, proteins, conjugates and excipients. Integrated Triple and Tetra Detector Arrays (TDAs) featuring Low Angle Light Scattering (LALS) detectors, four capillary differential viscometer detectors, refractometers and UV/VIS detectors; in a single experiment, obtain absolute molecular weight, molecular size, intrinsic viscosity, conformation, branching, aggregation and copolymer composition. Flow Injection Polymer Analysis (FIPA) for fast, accurate and precise average molecular weight, size and intrinsic viscosity in routine QA/QC and process control. Automated Dilute Solution Viscosity (DSV) systems provide relative, inherent, and intrinsic viscosity.