Viscotek - Setting the Standard for GPC
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Application Notes
Our database of GPC/SEC application notes explain the use of concentration, viscometer and light scattering detectors to obtain a distribution of absolute molecular weight, size and intrinsic viscosity, as well as information on conformation, aggregation, branching and copolymer composition.
Viscotek Applications
Viscotek Applications
Viscotek GPC ApplicationsViscotek specializes in solution techniques for macromolecular characterization. Gel Permeation Chromatography (GPC) is a solution technique which characterizes natural polymers such as polysaccharides and cellulosics; synthetic polymers such as adhesives, epoxies and plastics; and biopolymers such as proteins and protein conjugates by their distribution of absolute molecular weight, molecular size and intrinsic viscosity. Due to the richness of the GPC experiment, additional information can also be obtained on macromolecular structure, conformational changes, branching, aggregation and conjugate and copolymer composition.

Like Gel Permeation Chromatography, Flow Injection Polymer Analysis (FIPA) is used to characterize natural and synthetic polymers and biopolymers. However, the simplified separation mechanism employed in this technique delivers an average molecular weight, size and intrinsic viscosity rather than a distribution of these parameters. This absence of separation complexity makes it ideal for industrial process control in natural polymer applications such as methocellulose and synthetic polymer applications such as elastomers, polycarbonate, polyurethane and polypropylene.

Viscotek DSV Applications Dilute Solution Viscosity (DSV) is a widely practiced technique in the industrial market for the determination of relative viscosity. The relative viscosity typically correlates to the molecular weight and is used for calculation of the inherent viscosity, a product release specification for most industrial synthetic commodity polymer producers. Common applications include synthetic polymers such as PET, PVC, Nylon and various polyolefins, as well as natural polymers such as starch, cellulose and polylactic acid and biopolymers such as hyaluronic acid.

Dynamic Light Scattering (DLS) is a solution technique that is usually employed in the biopharmaceutical market. The small sample volumes and concentration requirements, quick turn-around time for sample analysis and the information provided (Rh or molecular size) make it ideal for applications involving proteins and protein denaturation. It is also frequently employed as a quick screening method for protein aggregation in the crystallography lab and for looking at protein stability.
Complete Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) systems for the characterization of natural and synthetic polymers, proteins, conjugates and excipients. Integrated Triple and Tetra Detector Arrays (TDAs) featuring Low Angle Light Scattering (LALS) detectors, four capillary differential viscometer detectors, refractometers and UV/VIS detectors; in a single experiment, obtain absolute molecular weight, molecular size, intrinsic viscosity, conformation, branching, aggregation and copolymer composition. Flow Injection Polymer Analysis (FIPA) for fast, accurate and precise average molecular weight, size and intrinsic viscosity in routine QA/QC and process control. Automated Dilute Solution Viscosity (DSV) systems provide relative, inherent, and intrinsic viscosity.